Evidence Based Strategies for Abatement of Harms from the Opioid Epidemic

Jointly produced by several national addiction experts, this comprehensive report contains recommendations and evidence-based strategies for investment of litigation settlement funds to end the opioid crisis and mitigate future harms.

This report was designed to support and empower state and local officials in making critical allocation decisions and consolidates the best research evidence to provide recommendations for high-impact investments that will improve the addiction treatment system, strengthen prevention and harm reduction programming, and address substance use disorder within the criminal justice system. In addition to outlining the scientific support for each recommendation, the authors include detailed guidance related to economic impacts and policy considerations.

The contributing authors are foremost experts in their fields and represent organizations including: Harvard T. H. Chan School of Public Health; Johns Hopkins Bloomberg School of Public Health; Yale University; Carnevale Associates, LLC; Partnership to End Addiction; Legal Action Center; University of Michigan School of Public Health; Stanford University; University of Pennsylvania, Perelman School of Medicine; Friends Research Institute; Vanderbilt University School of Medicine; RAND Corporation; and University of Pittsburgh. Funding support was provided by Arnold Ventures.

© 2026 Opioid COBRE | Rhode Island Hospital
This website is supported by the COBRE on Opioids and Overdose funded by the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM125507. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.