COBRE Projects

Since the COBRE on Opioids and Overdose’s inception in 2018, it has supported over 35 Investigators, 9 Pilot Projects, 4 Research Projects and 3 Research ‘Cores.’

Please explore the projects by hovering over the investigators pictures below. 

Adam Cynski, DO

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Jaclyn White Hughto, PhD, MPH

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Kirsten Langdon, PhD

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Stephen J. Kogut, PhD MBA RPh

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Rachel S. Wightman, MD

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David Sobel, MD

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Nicole Weiss, PhD

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Brendan Jacka, PhD

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Mainstay

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Block MMP

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The We-Can App

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Francesca Beaudoin, MD, PhD

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Sara Becker, PhD

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Amy Salisbury, PhD

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Patience Moyo, PhD

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In addition to providing funding and mentorship to COBRE Junior Investigators, the COBRE also supports smaller, short-term projects related to opioids and overdose. Below are some of our current COBRE-supported projects and partnerships. 

Exhibition on Overdose Prevention Sites 

3/15/2021 – 8/31/2021 

RICARES and Dr. Alexdra Collins, Brown University 

This exhibition will broaden the discussion around harm reduction interventions across Rhode Island’s many communities. The exhibition will present an accurate portrayal of a potential OPS model and its function and features; its goal is to demystify popular myths about these spaces and foreground the benefits of such interventions in saving lives. The exhibition would be located in the RICARES gallery, which features floor-to-ceiling windows and is situated at street-level on Mathewson Street in Downtown Providence. This placement maximizes the exhibitions’ visibility and allows the community to see the mock OPS while maintaining COVID safety procedures. Exhibition attendees will also be able to schedule appointments to view the exhibition during pre-determined gallery hours, staffed by RICARES’ team.

Experiences of Buprenorphine Treatment during the COVID-19 Pandemic 

1/1/2021 – 11/1/2022 

Dr. Rahul Vanjani, RI Hospital 

The objective of the present study is to examine the preliminary association of the COVID-19 pandemic with the provision of buprenorphine treatment and patient-level outcomes across three outpatient buprenorphine clinics affiliated with the largest hospital system in the state of Rhode Island. We hypothesize there are time-sensitive changes that are occurring to buprenorphine treatment as a result of COVID-19.  Information obtained through this study will identify key factors that may influence implementation of a low threshold approach following the COVID-19 pandemic. Additionally, this proposal seeks to empirically evaluate a) changes to buprenorphine prescribing practices and treatment, and b) how changes to the delivery of care impact patient-level outcomes. Results of this study may be leveraged to inform best-practice guidelines for buprenorphine prescribing to ensure safety and efficacy of OUD treatment. 

Factors Associated with Establishment of Emergency Department-Initiated Buprenorphine Induction in for Opioid Use Disorder Rural New England

11/1/2019 – 5/1/2020

Dr. Noah Rosenberg, The Miriam Hospital

The opioid epidemic in the United States continues to grow1 and evidence suggests that rural areas are disproportionately affected2. Although there is extensive heterogeneity within this trend, a rural burden is especially prominent in New England.3 Buprenorphine, an effective treatment for opioid use disorder (OUD), may be particularly difficult to deliver to rural areas due to lack of rural-based buprenorphine prescribers4. Urban Emergency Departments (EDs) have been shown to provide an important link to initiation of buprenorphine treatment5, however little is known regarding the extent to which ED-initiated buprenorphine is available in rural areas or the barriers and facilitators to starting such a program. These factors may be substantially different from those faced by an urban center due to the small scale and financially tenuous position of many rural hospitals6,7. Other investigators have conducted qualitative analysis of barriers and facilitators to buprenorphine treatment in the rural primary care setting,8 but no similar assessment has been conducted for emergency departments. The objective of the proposed study is to develop a context-rich analysis of barriers and facilitators to ED-initiated buprenorphine in rural New England from the perspective of emergency department directors at these sites, the professionals best situated to comment on potential benefits and challenges. This will be a qualitative, interview-based study with thematic analysis of interview transcripts to provide a context-rich perspective on the emergency department response to the opioid crisis in rural New England. This initial study is based on clinical experience suggesting that rural New England emergency departments face a unique set of challenges in the implementation of programs to provide buprenorphine induction to patients in need. This study will provide a foundation upon which future work can build.

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This website is supported by the COBRE on Opioids and Overdose funded by the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM125507. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.